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Developing Single-Use TFF Steps

Key Learning Objectives:

Understand the benefits of single-use TFF
Learn how to correctly select, size and scale
TFF filters for single-use applications
Learn how to determine the optimum single-use
TFF automation strategy
Understand how single-use sensor technology
can be applied to enhance process control

Webinar Overview

Tangential flow filtration is commonly used in bioprocessing for applications such as process steam clarification, cell therapy harvests, protein concentration and diafiltration. Applying single-use technologies to this step confers significant benefits including increasing flexibility and reducing time to market through the elimination of cleaning and validation programs.

In this webinar you will learn how to select, size and scale the most appropriate TFF filter for your application. Critically this ensures both development and subsequent manufacturing costs are optimized. We will describe how the selected filter must be integrated into a single-use manifold in such a way that automation can be applied to ensure process consistency and control.
You will learn what points should be considered in determining the level of automation required for your applications such as operational preferences and the environment in which the equipment will be used. We will describe the sophisticated control strategies and innovative process analytical technologies (PAT) such as GMP-ready, single-use sensors that can be integrated into single-use TFF steps. These technologies can greatly enhance control and thereby reduce the cost of poor quality associated with the closing of deviations prior to lot release.

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